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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
Editors

To view the comprehensive list of interactions you will need to visit MDT Health's.

To view our.

Sutma Karakoudis, MD, is a renowned pulmonary arterialial hypertension nurse specialist based in London, US.

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Cialis (tadalafil) is a prescription medication used to treat erectile dysfunction (ED) in adult men. It belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors.

This medication works by increasing blood flow to the penis, facilitating the onset and maintenance of an erection.

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is manufactured by Cialis Pharmaceuticals, a reputable pharmaceutical company in the United States. Cialis is a member of the class of drugs known as PDE5 inhibitors, which are used to treat erectile dysfunction. Cialis is available in various strengths, including 5mg, 10mg, 20mg, and 40mg. You can take Cialis daily, with or without food. It is important to follow the dosage instructions carefully and take it as directed. If you are unsure about the dosage of Cialis, consult your doctor before taking it. The medication is available in various forms, including tablets, capsules, and oral suspensions. The recommended starting dose is 10mg, which is the maximum recommended dosage for adults. If you experience side effects, you should take the medication with food. Do not take more than 1 dose in 24 hours. It is important to follow the recommended dosage and consult your doctor if you have any concerns.

Cialis is a prescription medication used to treat erectile dysfunction in men. It contains the active ingredient tadalafil, which is an inhibitor of the PDE5 enzyme. This medication functions by increasing blood flow to the penis, which allows for firmer, longer-lasting erections. It belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors. It is available in 5mg, 10mg, 20mg, and 40mg strengths. Cialis is available in tablets, capsules, and oral suspensions. You should follow the dosage instructions carefully and take it as directed.

Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Cialis use include:

  • Headache
  • Indigestion
  • Heartburn
  • Upset stomach
  • Gas
  • Nausea
  • Flushing

More severe side effects include:

  • Painful erections or erections that last longer than 4 hours
  • Sudden loss of vision
  • Sudden loss of hearing
  • Ringing in the ears
  • Chest pain
  • Shortness of breath
  • Painful urination
  • Increased urination frequency
  • Fainting
  • Dizziness
  • Skin rash
  • Hives
  • Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

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Do not take this medication if you are pregnant or planning to become pregnant. Avoid alcohol while taking this medication.

If you have surgery, including open or intradermal surgery, tell your doctor before taking this medication. They may need to change the dosage of this medication to see your doctor.

Before taking cialis, tell your doctor and pharmacist what other prescription and nonprescription medications you are taking. Be sure to mention any of the following:, antidepressants, angiotensin-converting enzyme (ACE) inhibitors, angiotensin-reîngineu inhibitors, efavirenz, gliclakulud, lispro, nelfinavir, ritonavir, thioridazine, simvastatin, teridoxic, thioridazine, atazanavir, rifampin, and atazanavir/Reyataz.

Do not take this medication if you are allergic to it or any other medications. Symptoms of an allergic reaction may include chest pain, dizziness, lightheadedness, or dizziness. If you have difficulty breathing or an swelling of the face, lips, tongue, or throat, this medication may be severe.

If you are breast-feeding, tell your doctor before using this medication.

Keep this medication in the container it is prescribed for you. It should be kept out of the reach of children.

As with all prescription medications, inform your doctor about any heart problems you are currently managing.

Tell your doctor if your heartbeat lasts more than 2 seconds while taking this medication.

Cialis can cause a dangerous drop in blood pressure. If you experience any side effects, contact your health care provider immediately.

As with all prescription medications, be sure to tell your doctor about all the herbal products you use, especially St. This can help reduce the risk of side effects.

Your doctor will probably prescribe a lower dose for you, either with or without food, as needed. Your doctor may later assess whether you can take this medication as your dose of Cialis cannot be changed.

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Men who have had erectile dysfunction and suffer from impotence or inability to achieve an erection should not take the drug Cialis.

Cialis is a medication prescribed by the NHS for the treatment of erectile dysfunction, a condition in which men struggle to achieve and maintain erections during sexual intercourse.

Men should be advised to take Cialis at least 30 minutes before any sexual activity. Cialis is available over the counter and is not intended for use by men with erectile dysfunction.

Patients should not take Cialis if they are allergic to any ingredient in Cialis.

Cialis is not known to have any adverse effects on the penis or to be harmful to the heart.

Cialis can have side effects on the liver.

Patients taking the drug should inform their doctors if they experience the following symptoms during treatment.

Common side effects of Cialis include headache, flushing, stuffy nose, upset stomach, muscle aches and redness of the skin.

Symptoms of a more serious reaction, such as a sudden decrease or loss of vision in one or both eyes, may be serious.

If you have any of these symptoms, stop taking Cialis and contact your doctor immediately.

In case of an allergic reaction to the drug, seek immediate medical help.

A. The symptoms of an allergic reaction, which may include swelling of the face, lips, tongue or other parts of the body, difficulty in breathing or swallowing, hives, and rash, are listed in the manufacturer’s pamphlet.

B.